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Category:2005 video games
Category:Grand Theft Auto
Category:PlayStation 2 games
Category:Video games developed in Canada
Give a voice to the voiceless and the world will hear you: the EA Sports series of games is one of the biggest names in video games, and EA have brought this to Switch this year with FIFA 18, a sports game that plays out in 3D and features some of the best players ever on the pitch.
A few key additions with this version of the game from FIFA 17 — you can pre-order your game with a disc version and will get your hands on it later this year, plus the FIFA 18 season pass is included for all you FIFA fans out there, and the EA SPORTS Ultimate Team is making its first appearance on the Switch this year — you can expect to get all those extras included in your
Jun 15, 2019
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Category:1990 video games
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Category:Video games developed in the United States
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Category:Video games set in San Andreas
Category:Video games set in the United StatesL-arabinose protects human endothelial cells from apoptosis induced by homocysteine.
Hyperhomocysteinemia (HHcy) is an independent risk factor for thrombotic cardiovascular disease. The pathogenesis of cardiovascular disease has been recognized to be closely related to the balance of pro- and anti-apoptotic proteins. In recent studies, L-arabinose was found to protect vascular endothelial cells from apoptosis in vitro. However, whether L-arabinose can prevent endothelial cell apoptosis induced by HHcy is unclear. In this study, we investigated whether L-arabinose could protect human endothelial cells from apoptosis induced by homocysteine (Hcy). Human endothelial cells (EA.hy926) were incubated with 10-100 microM Hcy in the presence of L-arabinose (1-10mM) for 48h. Apoptosis was determined by flow cytometry and TUNEL assay. Our results show that Hcy increases apoptosis in EA.hy926 cells in a dose- and time-dependent manner, and that L-arabinose has anti-apoptotic effect on endothelial cells incubated with 10-100 microM Hcy. The effect of L-arabinose on Hcy-induced endothelial cell apoptosis was increased with concentration. Moreover, L-arabinose decreases intracellular reactive oxygen species, total glutathione, reduced glutathione, and GSH/GSSG ratio in 10 microM Hcy-treated endothelial cells. These results suggest that L