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Thyroid dysfunction (TD) is one of the most frequent side effects of IFN-β treatment. Most of the published reports are case reports. The frequency of TD in MS patients treated with IFN-β remains unknown. To study the frequency of TD in a cohort of MS patients treated with IFN-β and to identify risk factors for its development. This was a retrospective cohort study of patients with a diagnosis of MS treated with IFN-β at San Raffaele Scientific Institute or the University of Cologne. Records were screened and patients with TD were identified. A total of 721 patients (470 females, 251 males) with a mean age of 32.5 ± 8.4 years were recruited. TD was documented in 92 (12.5 %) patients and